Jerzy M. Twarowski, PhD
Genome Instability | Computational Genomics | Mutagenesis | Fungal Evolution
Embedded Files
I combine experimental genetics and computational genomics to uncover how genome instability drives mutagenesis, genome evolution, and drug resistance.
Featured Research
Nature Communications (2026)
Break-induced replication forms long hypermutable ssDNA during meiosis
Revealed that DNA repair of meiotic breaks can create extensive tracts of mutable single-stranded DNA, providing a mechanistic link between genome instability and germline evolution.
Nucleic Acids Research (2022)
Migrating bubble synthesis promotes mutagenesis through lesions in its template
Identified a novel mechanism by which DNA damage is can lead to mutagenesis during DNA repair.
----- View all publications -----
Featured Software
Python-based toolkit for analysis of recombination-associated mutagenic ssDNA during yeast meiosis. Associated with 2026 Nature Communications Publication.
LOHness
LOHness
Loss of Heterozygosity (LOH) breakpoint caller for Illumina WGS which builds an ad hoc low-noise SNP panel from cohort data. Created for analysis of highly heterozygous diploid genomes like Candida albicans.
----- View all projects -----
Page updated
Google Sites
Report abuse