I am a Postdoctoral Researcher at the University of Minnesota (Selmecki Lab) specializing in genetics, bioinformatics, and DNA repair. My work integrates molecular biology with computational biology to study how antifungal treatment leads to genomic instability and how genomic instability leads to antifungal resistance.
Previously, as a PhD candidate at the University of Iowa , I investigated the mutagenic consequences of Break-Induced Replication (BIR). My research uncovered that BIR generates mutagenic single-stranded DNA not only on the lagging strand but also on the leading strand template (D-BTS). I further showed that similar error-prone pathways operate during meiosis and are capable of creating mutation clusters.
My technical expertise includes developing custom bioinformatic workflows for Next-Generation Sequencing (NGS) analysis. I created the MMBSearch pipeline for annotation of Microhomology-Mediated BIR (MMBIR) signatures in TCGA cancer datasets and MayoMate to find, visualize, quantify and correlate meiotic recombination events with ssDNA tracts by utilizing WGS data.